When it comes to a Nike running shoe comparison, the choices can be overwhelming. Whether you’re a seasoned marathoner or just lacing up for your first jog, finding the perfect shoe is crucial for performance and injury prevention. That’s why we’ve put together this comprehensive guide. In this detailed Nike running shoe comparison, we’ll break down four of Nike’s most popular road running shoes—the Vomero 16, the Pegasus Turbo Next Nature, the Interact Run, and the Structure 25. Our goal is to help you easily find the right shoe for your specific running needs, so you can hit the road with confidence.

Nike Running Shoe Comparison:

Feature	Nike Air Zoom Vomero 16	Nike Pegasus Turbo Next Nature	Nike Interact Run	Nike Structure 25
Primary Use	Daily training, long runs, recovery runs	Tempo runs, short to medium distance, daily trainer	Casual running, walking, and daily wear; a budget-friendly option	Stability trainer for daily runs, easy runs, and overpronation support
Cushioning	ZoomX and Zoom Air. Dual-density midsole with a soft, energy-returning ZoomX core and a firmer carrier foam for stability.	Full-length ZoomX midsole made from recycled Nike foam scraps. This gives it a responsive feel while being more sustainable.	Soft, responsive foam midsole with a high stack height for a plush ride.	Cushlon 3.0 foam with a forefoot Zoom Air unit. Provides supportive and balanced cushioning.
Ride Feel	Plush, smooth, and highly cushioned. It prioritizes comfort and shock absorption over speed.	Firm, snappy, and responsive. Provides a bouncy, energetic feel that encourages a faster pace.	Soft and comfortable. Provides a smooth ride suitable for easy runs and daily activities.	Stable and durable. The ride is firm but well-cushioned, and the rocker geometry aids in a smoother transition.
Upper	Engineered mesh with a secure midfoot band and a plush, padded tongue and heel collar for a comfortable, locked-in fit.	Stretchy and breathable Flyknit upper. It’s lighter and provides a sock-like fit, but some runners may find the heel less secure.	Lightweight and durable Flyknit upper with targeted zones of breathability.	Plush, single-layer engineered mesh upper with plenty of foam padding in the tongue and heel for comfort and a secure fit.
Weight	Heavier, which contributes to its durability and cushioning.	Lighter and more flexible, making it ideal for picking up the pace.	Lightweight (approx. 260g for men’s US 10) for a comfortable feel.	Heavier than the Pegasus, but offers more cushioning and stability. (Approx. 289g for men’s US 10).
Outsole	Highly durable carbon rubber outsole with aggressive lugs for reliable traction and longevity.	Waffle-inspired tread pattern with exposed midsole foam in some areas. It is designed for traction but may show wear more quickly than the Vomero.	Rubber waffle outsole made with recycled Nike Grind material for traction.	Durable waffle outsole with lugs and vertical grooves for grip and stability.
Stability	More stable due to its wider base and firmer carrier foam.	Less stable due to the softer nature of the foam and a lack of a plate, which can cause some flex in the midfoot.	A neutral trainer with a wide base, but less stable than the Vomero or Structure.	Very stable due to its midfoot support system, built-up medial side, and wide base, making it suitable for overpronators.
Best For…	Runners who want maximum comfort and cushioning for long, easy miles. It’s a fantastic option for a high-mileage daily trainer.	Runners who want a versatile, lightweight shoe for both daily runs and faster workouts. Its responsiveness makes it a great choice for tempo days.	New runners or those who want a versatile, comfortable shoe for casual runs, walking, and daily wear at an affordable price.	Runners who need a supportive and stable daily trainer for easy or recovery runs, especially those who overpronate.
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Expert Recommendation

The choice between these shoes ultimately comes down to your primary running needs. If you prioritize comfort and durability for long, easy runs and want a shoe that can handle high mileage, the Vomero 16 is the clear winner. If you’re looking for a lighter, more responsive shoe for a variety of paces and want a bouncier feel, the Pegasus Turbo Next Nature is the shoe for you. For a budget-friendly and versatile option that can handle both running and daily wear, the Interact Run is a great choice. Finally, if you need a daily trainer with enhanced stability and support, the Structure 25 is the shoe for you.